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KMID : 0367420050480010006
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Journal of Korean Pediatric Society
2005 Volume.48 No. 1 p.6 ~ p.12
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Helper T Cell Polarizing Through Dendritic Cells
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Han Man-Yong
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Abstract
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In the last few years, a spectrum of dendritic cells(DCs), including toll like receptors(TLRs), might play a critical role in regulating allergy and asthma. DC plays a central role in initiating immune responses, linking innate and adaptive responses to pathogen. Human peripheral blood has three non- overlapping dendritic subset that expressed various 11 TLRs. These dendritic subsets and TLR contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. A better understanding of DC immunobiology may lead to the comprehension of allergy pathophysiology to prevent early stage allergic march.
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KEYWORD
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Toll like receptor, Plasmacytoid dendritic cell, Myeloid dendritic cell, Th1/Th2 deviation
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